TABLE 2.
Comparison of baselines laboratory features between systemic sclerosis with or without interstitial lung disease.
| Variables | Total (n = 227) | SSc with ILD (n = 121) | SSc without ILD (n = 106) | P * |
| WBC (×109/L), median (IQR) | 5.9 (3.2) | 6.4 (3.1) | 5.4 (2.5) | 0.001# |
| Neutrophils (×109/L), median (IQR) | 3.7 (2.6) | 4.1 (2.9) | 3.4 (2.0) | 0.005# |
| Lymphocytes (×109/L), median (IQR) | 1.4 (0.7) | 1.4 (0.7) | 1.4 (0.6) | 0.920# |
| Platelet (×109/L), median (IQR) | 212.0 (98.0) | 238.0 (107.5) | 194.5 (104.3) | 0.001# |
| NLR, median (IQR) | 2.6 (2.1) | 2.7 (2.5) | 2.5 (1.4) | 0.038# |
| PLR, median (IQR) | 150.6 (93.2) | 160.0 (97.3) | 139.1 (79.4) | 0.010# |
| CK, median (IQR) | 83.4 (86.4) | 80.2 (111.6) | 84.5 (71.0) | 0.881# |
| Elevated ferritin | 49 (21.6) | 34 (28.1) | 15 (14.2) | 0.011 |
| Elevated KL-6 | 135 (59.5) | 82 (67.8) | 53 (50.0) | 0.007 |
| Elevated ESR | 170 (74.9) | 92 (76.0) | 78 (73.6) | 0.671 |
| Elevated CRP | 60 (26.4) | 37 (30.6) | 23 (21.7) | 0.130 |
| IgG (g/L), median (IQR) | 16.1 (8.1) | 16.2 (9.1) | 15.8 (6.5) | 0.578# |
| IgA (g/L), median (IQR) | 2.7 (2.0) | 3.0 (1.9) | 2.5 (2.1) | 0.438# |
| IgM (g/L), median (IQR) | 1.4 (0.9) | 1.4 (0.9) | 1.3 (0.9) | 0.368# |
| C3 (g/L), median (IQR) | 0.8 (0.2) | 0.9 (0.2) | 0.8 (0.2) | 0.175# |
| C4 (g/L), median (IQR) | 0.2 (0.1) | 0.2 (0.1) | 0.2 (0.1) | 0.245# |
| ANA | 178 (78.4) | 104 (86.0) | 74 (69.8) | 0.003 |
| Anti-Scl-70 | 90 (39.6) | 58 (47.9) | 32 (30.2) | 0.006 |
| ACA | 58 (25.6) | 23 (19.0) | 35 (33.0) | 0.016 |
| Anti-SSA | 71 (31.3) | 42 (34.7) | 29 (27.4) | 0.233 |
| Anti-SSB | 14 (6.2) | 7 (5.8) | 7 (6.6) | 0.798 |
| Anti-Ro-52 | 96 (42.3) | 58 (47.9) | 38 (35.8) | 0.066 |
| Anti-u1-RNP | 59 (26.0) | 32 (26.4) | 27 (25.5) | 0.867 |
| RF | 73 (32.2) | 44 (36.4) | 29 (27.4) | 0.147 |
Values are the n (%) unless otherwise indicated. *Chi-square test was used to compare systemic sclerosis with or without interstitial lung disease groups unless otherwise indicated. #Mann–Whitney U-test. SSc, systemic sclerosis; ILD, interstitial lung disease; WBC, white blood cell; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; CK, creatine kinase; KL-6, Krebs von den Lungen-6; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; IgG, immunoglobulin G; IgA, immunoglobulin A; IgM, immunoglobulin M; C3, complement 3; C4, complement 4; ANA, anti-nuclear antibody; Anti-Scl-70, anti-scleroderma-70; ACA, anti-centromere antibody; RF, rheumatoid factor; anti-u1-RNP, anti-u1-ribonucleoprotein.