. 2022 Dec 19;12:21886. doi: 10.1038/s41598-022-26094-1

Table 1.

pKa of TLR agonists and inhibitor of PD-1/PD-L1; and pH at which each drug dissolved for loading.

Drug	GARD	IMQ	GS-9620	DSR 6436	BMS-202	Dox
pKa	7.02 & 8.02 (measured) 6.97 and 7.71 (calculated)	7.3 (literature) ⁵²	6.53, 8.88, 9.50 (calculated)	4.58, 8.50 & 9.94 (measured)	7.74 (literature) ⁵⁴	8.2 (literature) ⁵³
pH (T in °C)	–	2.06 (20.1)	–	1.65 (20.1)	2.11 (20.1)	4.2 (21.1)

Drug

GARD

IMQ

GS-9620

DSR 6436

BMS-202

Dox

pKa

7.02 & 8.02 (measured)

6.97 and 7.71

(calculated)

7.3 (literature) ⁵²

6.53, 8.88, 9.50 (calculated)

4.58, 8.50 & 9.94 (measured)

7.74 (literature) ⁵⁴

8.2 (literature) ⁵³

pH (T in °C)

–

2.06 (20.1)

–

1.65 (20.1)

2.11 (20.1)

4.2 (21.1)