Table 2.
Drug | Doxorubicin HCl* | Gardiquimod | DSR 6434 | Imiquimod | BMS-202 |
---|---|---|---|---|---|
Maximum drug loaded, mg drug/ml beads | 204.54 ± 3.87 | 65.97 ± 1.54 | 65.95 ± 6.96 | 65.28 ± 3.09 | 148.05 ± 2.24 |
mM drug/ml beads equivalent of drug loaded to sulfonated bead | 0.35 ± 0.01 | 0.21 ± 0.00 | 0.16 ± 0.02 | 0.27 ± 0.01 | 0.35 ± 0.01 |
Theoretical maximum loading level based on SO3− contents (mg) | 166.5 | 89.95 | 114.94 | 68.97 | 120.4 |
Drug: sulfonate | 1.228 | 0.733 | 0.574 | 0.946 | 1.223 |
*Maximum loading reflects the amount of each drug in its basic form except for Dox which is available in its salt form.