Fig. 3.

Antiretroviral (ARV) drug levels in the liver and plasma. (a) Concentrations of ARVs in liver biopsies and plasma quantified by mass spec imaging are shown for liver (open circles) and plasma (filled circles). To directly compare liver and plasma ARV levels, plasma concentrations were converted from ng/mL to ug/g as described in the methods. (b) Representative images of ARV drug levels in liver biopsy sections. Lighter colours are associated with higher drug concentrations and darker colours are associated with lower drug concentrations. (c) Level of ARV coverage in the liver. FTC = emtricitabine, TFV = tenofovir, EFV = efavirenz, 3TC = lamivudine, RPV = rilpivirine. p values were determined by Wilcoxon signed-rank test. Boxes represent range with line at the median. ns = not significant. LOQ = limit of quantification. For panel c, statistics were not performed for 3TC and RPV due to low numbers. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.