Table 3.
HIFU treatment profile.
| Nil (N = 21) | Letrozole (N = 7) | GnRHa (N = 11) | p-value | |
|---|---|---|---|---|
| Sonication time (s) Median (range) |
739 (320–1,226) | 711 (345–887) | 1,137 (777–1,606) | 0.001 N vs. L: 0.972 N vs. G: 0.001 L vs. G: 0.009 |
| Treatment duration (min) Median (range) |
95 (47–158) | 94 (46–174) | 148 (96–237) | 0.002 N vs. L: 0.997 N vs. G: 0.003 L vs. G: 0.020 |
| Energy (J) Median (range) |
293,911 (127,850–490,100) | 282,639 (137,550–354,500) | 452,572 (310,350–642,100) | 0.001 N vs. L: 0.971 N vs. G: 0.002 L vs. G: 0.010 |
| Non-perfusion volume ratio (NPV, %), median (range) |
88.5 (61–100) | 96 (76–100) | 87.7 (72–98) | 0.231 N vs. L: 0.258 N vs. G: 0.978 L vs. G: 0.259 |
| Energy efficiency (E/V) (J/cm3), median (range) |
1,775.1 (424.5–5,609.1) | 1,010.4 (305.8–1,772.7) | 1,552.7 (404.8–4,123.7) | 0.425 N vs. L: 0.392 N vs. G: 0.894 L vs. G: 0.677 |
| Treatment speed (cm3/h) Median (range) |
187.8 (27.6–522.4) | 292.7 (59.6–612.4) | 187.9 (44.5–484.2) | 0.273 N vs. L: 0.272 N vs. G: 1.000 L vs. G: 0.344 |
| Power rate (J/h) Median (range) |
186,249.2 (104,604.8–277,933.3) | 197,004.7 (105,689.7–271,854.5) | 188,733.6 (145,369.9–284,812.5) | 0.863 N vs. L: 0.851 N vs. G: 0.988 L vs. G: 0.925 |
| Treat efficiency (NPV/min) Median (range) |
2.39 (0.37–5.69) | 4.52 (0.89–9.70) | 2.34 (0.55–7.05) | 0.050 N vs. L: 0.053 N vs. G: 0.997 L vs. G: 0.078 |
| NPV per energy (cm3/J) | 0.077 (0.039–0.151) | 0.074 (0.054–0.140) | 0.046 (0.030–0.063) | 0.012 N vs. L: 0.947 N vs. G: 0.010 L vs. G: 0.101 |
| NPV per sonication (cm3/s) | 30.96 (15.94–60.22) | 29.52 (21.08–55.84) | 18.09 (12.13–25.17) | 0.12 N vs. L: 0.953 N vs. G: 0.010 L vs. G: 0.098 |
GnRHa, gonadotrophin releasing hormone analog; HIFU, high intensity focused ultrasound; NPV, non-perfusion volume.