TABLE 2.
The top ten most significant biological process ontologies for genes that were upregulated or downregulated in response to DEX.
| Name | Count | Up | Down |
|---|---|---|---|
| Response to bacterium | 8 | CAV1, COLEC12, IRAK1, TICAM2, LPO | CFD, MPEG1, TLR4 |
| immune system process | 36 | TSPAN6, B4GALT1, CAV1, HSP90AB1, CD46, IMPDH2, CNOT7, COLEC12, STAT3, IRAK1, DDIT4, TICAM2, PHB, MPP1, LPO, GCNT1, FST, PTX3, SNX10 | VAV1, TLR3, BLA-DQB, TMEM106A, ALOX15, PSMB9, ENPP3, CD320, LGALS9, CASP4, CFD, LGALS1, SOD1, AQP3, MSN, PSMB10, TLR4 |
| actin cytoskeleton reorganization | 1 | — | PDLIM4 |
| positive regulation of fat cell differentiation | 1 | — | MEDAG |
| negative regulation of protein kinase activity | 7 | CAV1, HMGCR, DNAJA1, GSKIP | FABP4, TRIB2, WARS1 |
| heart contraction | 3 | SNTA1, CAV1 | SOD1 |
| cGMP-mediated signaling | 1 | PDE2A | — |
| female gonad development | 2 | FST | SOD1 |
| cellular response to cAMP | 1 | FDX1 | — |
| response to drug | 4 | — | FBP1, SOD1, PDE2A, SLC1A3 |