Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 19;13(12):1051. doi: 10.1038/s41419-022-05444-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — ERS and UPR are commonly induced in the liver in response to stimuli such as viruses, drugs, and high-fat diet (HFD). When stimulation is weak, it can be adaptively regulated by amino acid metabolism, redox reaction, protein degradation, and attenuated translation to maintain the normal physiological function of the liver. When the stimulation is enhanced or prolonged, it will cause cell death and lead to viral hepatitis, fatty liver injury, drug-induced liver injury (DILI), and even hepatocellular carcinoma (HCC). Therefore, ERS can also regulate cell death in the process of liver injury to achieve the therapeutic effect of liver injury.