Table 3.

Correlation of geneset enrichment scores between EWAS and GWAS

trait	n EWAS genes	n GWAS genes	Geneset overlap	obs cor	exp cor	p diff
Body mass index	232	3,228	1,243	0.187	0.20	0.2287
Current versus never smoking	1933	312	1,053	0.200	0.22	0.0343
Former versus never smoking	282	323	661	0.298	0.30	0.9936
Alcohol consumption per day	361	190	562	0.259	0.27	0.5753
C-reactive protein	189	302	600	0.265	0.26	0.7983
Educational attainment	25	1,594	215	0.105	0.13	0.1729
Fasting glucose	15	50	50	0.153	0.16	0.7723
Fasting insulin	36	5	19	0.093	0.12	0.4400
Systolic blood pressure	99	3,210	631	0.145	0.14	0.7679
Diastolic blood pressure	56	3586	594	0.160	0.11	0.0013
Birthweight	894	162	683	0.224	0.24	0.2476
Cognitive abilities: digit test	26	875	198	0.164	0.14	0.2064
FEV1	51	1,664	403	0.158	0.14	0.1948
eGFR	256	2611	1,264	0.233	0.20	0.0332
Urate	251	666	877	0.306	0.27	0.0414

For each geneset, odds of study genes being in the geneset divided by the odds of the study genes not being in the geneset were assessed and correlation between these odds ratios are given here.

exp cor = the mean correlation between odds ratios after repeating the analysis 1000 times, randomly sampling EWAS genes equal to the number identified in the empirical analysis.

geneset overlap indicates the number of gene ontology terms that map to both genes identified by the EWAS and GWAS.

p diff = P value from a two-sided Z-test assessing the difference between the observed and expected correlations.