Table 3.

KOOS-12 subscale differences at baseline, and changes at 3- and 12-month follow-up in participants with knee osteoarthritis.

	Baseline score	3-month follow-up		12-month follow-up
KOOS-12 pain adjusted model	Mean (95% CI)	Mean (95% CI)	Mean change from baseline (95% CI)	Mean (95% CI)	Mean change from baseline (95% CI)
No comorbid LSS symptoms (reference)	50.4 (49.8–51.0)	60.9 (60.3–61.6)	10.5 (9.9–11.2)	64.6 (63.9–65.3)	14.2 (13.6–14.9)
	Mean difference (95% CI)	Mean difference (95% CI)	Difference in change from baseline (95% CI)	Mean difference (95% CI)	Difference in change from baseline (95% CI)
Comorbid LSS symptoms	−3.2 (−4.7 to −1.8)	−5.0 (−6.6 to −3.4)	−1.7 (−3.3 to −0.1)	−3.6 (−5.2 to −2.0)	−0.3 (−1.9 to 1.3)
KOOS-12 function adjusted model	Mean (95% CI)	Mean (95% CI)	Mean change from baseline (95% CI)	Mean (95% CI)	Mean change from baseline (95% CI)
No comorbid LSS symptoms (reference)	57.1 (56.6–57.7)	66.4 (65.8–67.1)	9.3 (8.7–9.9)	68.7 (68.1–69.4)	11.6 (11.0–12.2)
	Mean difference (95% CI)	Mean difference (95% CI)	Difference in change from baseline (95% CI)	Mean difference (95% CI)	Difference in change from baseline (95% CI)
Comorbid LSS symptoms	−5.0 (−6.5 to −3.5)	−5.2 (−6.9 to −3.5)	−0.2 (−1.8 to 1.4)	−4.6 (−6.3 to −2.9)	0.4 (−1.2 to 2.0)
KOOS-12 quality of life adjusted model	Mean (95% CI)	Mean (95% CI)	Mean change from baseline (95% CI)	Mean (95% CI)	Mean change from baseline (95% CI)
No comorbid LSS symptoms (reference)	46.3 (45.8–46.9)	52.9 (52.3–53.5)	6.6 (6.0–7.2)	56.6 (56.0–57.3)	10.3 (9.7–10.9)
	Mean difference (95% CI)	Mean difference (95% CI)	Difference in change from baseline (95% CI)	Mean difference (95% CI)	Difference in change from baseline (95% CI)
Comorbid LSS symptoms	−3.4 (−4.8 to −2.0)	−3.6 (−5.2 to −2.1)	−0.2 (−1.7 to 1.3)	−3.2 (−4.9 to −1.6)	0.2 (−1.4 to 1.7)

KOOS-12: Knee injury and Osteoarthritis Outcome Score 12 item short form (0–100, worst-best).