Table 4:
Multivariable analysis of risk factors for bronchopulmonary dysplasia
| Factor | BPD (n=332) | No BPD (n=489) | aOR (95%) CI | Change in odds per |
|---|---|---|---|---|
| Clinical Characteristics | ||||
| Received ≥ 1 dose of antenatal steroids, n (%) | 292 (88%) | 453 (93%) | 0.67 (0.38, 1.16) | yes vs. no |
| Female sex, n (%) | 159 (48%) | 237 (48%) | 1.02 (0.75, 1.38) | yes vs no |
| Black race*, n (%) | 80 (25%) | 130 (27%) | 0.85 (0.58, 1.22) | yes vs no |
| Birth weight, mean g (sd) | 794 (189) | 823 (185) | 0.95 (0.86, 1.05) | 100 g increase |
| Small for gestational age, n (%) | 49 (15%) | 69 (14%) | 1.06 (0.70, 1.61) | yes vs no |
| Delivery Room Intubation, n (%) | 265 (80%) | 388 (79%) | 0.79 (0.59, 1.07) | yes vs. no |
| Chorioamnionitis, n (%) | 31 (11%) | 71 (15%) | 0.80 (0.51, 1.25) | yes vs. no |
| Surfactant on DOB, n (%) | 237 (71%) | 340 (70%) | 1.01 (0.71, 1.42) | yes vs. no |
| Caffeine on DOB, n (%) | 235 (71%) | 326 (67%) | 1.16 (0.82, 1.64) | yes vs. no |
| Enteral Iron Exposure | ||||
| Mean mg/kg/day (sd) through 28 days | 1.49 (1.50) | 1.83 (1.62) | 0.89 (0.80, 0.99) | 1 mg/kg/day increase |
| Mean mg/kg/day (sd) through 36 weeks | 3.09 (1.85) | 3.25 (1.87) | 1.02 (0.93, 1.12) | 1 mg/kg/day increase |
| IV Iron Exposure | ||||
| Mean mg/kg/day (sd) through 28 days | 0.10 (0.13) | 0.08 (0.12) | 1.05 (0.92, 1.20) | 0.1 mg/kg/day increase |
| Mean mg/kg/day (sd) through 36 weeks | 0.05 (0.07) | 0.04 (0.06) | 1.07 (0.84, 1.38) | 0.1 mg/kg/day increase |
| Packed Red Blood Cell Transfusions | ||||
| Mean ml/day (sd) at 28 days | 1.52 (1.24) | 0.91 (1.23) | 1.20 (1.02, 1.41) | 1 ml/day increase |
| Mean ml/day (sd) at 36 weeks | 0.81 (0.72) | 0.53 (0.86) | 1.04 (0.86, 1.26) | 1 ml increase |
| PENUT Trial Treatment Arm | ||||
| Received erythropoietin | 172 (52%) | 243 (50%) | 1.14 (0.85, 1.54) | yes vs. no |
The multivariable regression model was adjusted for recruitment site, gestational age at birth, and randomization assignment.
*
Black race compared to white or other race.