Table 2.

Patient and family history in relation to the etiology of MMR-D.

History	No. of patients (%)			P value	Pairwise P values
	HM-MSI (n = 103)	LS-MSI (n = 28)	DS-MSI (n = 17)
Met diagnostic criteria
Revised Bethesda	40 (39)	26 (93)	13 (77)	<0.001	<0.0001,a 0.007,b 0.179c
Amsterdam III	0	10 (36)	0	<0.001	<0.0001,a 0.007c
Personal history
Metachronous CRC	4 (4)	8 (29)	0	<0.001	0.0005,a 1.000,b 0.017c
Synchronous CRC	3 (3)	1 (4)	0	0.752
LS-related neoplasmsd	4 (4)	3 (11)	0	0.199
Family history
CRC	37 (36)	22 (79)	5 (29)	<0.001	<0.0001,a 0.785,b 0.002c
LS-related neoplasmsd	22 (21)	14 (50)	5 (29)	0.012	0.004,a 0.532,b 0.222c

Abbreviations: CRC, colorectal cancer; DS, double somatic; HM, hypermethylation; MMR-D, mismatch repair deficient; LS, Lynch syndrome; MSI-H, microsatellite instability-high.

^aHM-MSI vs LS-MSI

^bHM-MSI vs DS-MSI

^cLS-MSI vs DS-MSI

^dNoncolorectal