TABLE 1.

Related traits of homocysteine-associated SNPs.

SNPs	Nearest	Chr	EA	EAF	Association with hcy			Association with outcomes
								NAFLD		NASH		Cirrhosis
	gene				beta	se	p-value	beta	se	beta	se	beta	se
rs1801133	MTHFR	1	A	0.34	0.1583	0.007	4.34E-104	0.063	0.042	−0.037	0.168	−0.142	0.058
rs2275565	MTR	1	T	0.21	-0.0542	0.009	1.96E-10	0.044	0.044	−0.020	0.173	−0.020	0.060
rs9369898	MUT	6	A	0.62	0.0449	0.007	2.17E-10	−0.012	0.037	0.297	0.146	0.052	0.050
rs7130284	NOX4	11	T	0.07	-0.1242	0.013	1.88E-20	−0.008	0.053	−0.244	0.210	0.029	0.072
rs154657	DPEP1	16	A	0.45	0.0963	0.007	1.74E-43	0.043	0.037	0.144	0.147	0.054	0.051
rs4660306	MMACHC	1	T	0.33	0.0435	0.007	2.33E-09	0.000	0.038	−0.036	0.150	0.102	0.052
rs548987	SLC17A3	6	C	0.13	0.0597	0.01	1.12E-08	0.014	0.063	−0.216	0.251	-0.114	0.087
rs42648	GTPB10	7	A	0.40	-0.0395	0.007	1.97E-08	-0.013	0.037	-0.069	0.147	0.000	0.051
rs1801222	CUBN	10	A	0.34	0.0453	0.007	8.43E-10	0.049	0.038	−0.057	0.153	-0.030	0.053
rs2251468	HNF1A	12	A	0.65	-0.0512	0.007	1.28E-12	-0.047	0.037	0.252	0.146	0.026	0.050
rs838133	FUT2	19	A	0.45	0.0422	0.007	7.48E-09	0.013	0.037	0.099	0.148	0.025	0.051
rs12780845	CUBN	10	A	0.65	0.0529	0.009	7.80E-10	-0.081	0.041	0.236	0.165	-0.021	0.057

Chr., chromosome; EA, effect allele; EAF, effect allele frequency.