FIGURE 4.

Mitochondrial remodelling and state of health in I/R condition. (A) mPTP involvement in IRI. Schematic representation of the main molecular events involving mPTP in IRI. During ischemia mPTP opening is inhibited, after reperfusion this multiprotein complex opening triggers mitochondrial reactions which lead to cardiomyocytes death. (B). Mitochondrial biogenesis. The biogenic process is activated during ischemia with positive consequences in order to improve cellular metabolism and energy production and to promote cardiac regeneration. (C). Mitochondrial dynamics. Fission process is enhanced during I/R leading to tissue injury. Contrariwise, mitochondrial fusion is reduced and increase of this process showed beneficial effects against IRI. (D). Mitophagic process. Induction of mitophagy during myocardial infarction has cardioprotective effects on the condition that is not a chronic activation, very harmful for cardiac tissue.