Fig. 4.

Structure and function of NADK. (A) A schematic representation of the NADK domains, including phosphorylation sites, GGDG motif, NE/D short motif, conserved region II (CCII), NAD⁺ binding region and oligomerization region. (B) Critical amino acid residues for catalysis, NAD⁺ recognition and oligomerization. Underlines indicate the GGDG motif, NE/D short motif, and conserved region II. Highlighting indicates residues involved in the kinase reaction and binding to NAD⁺. Open circles indicate residues involved in oligomerization.