Figure 1.

Meclozine rescues impaired cortical bone mineralization in Hyp mice. Representative non-decalcified histological images of the (A) femur and (B) tibia stained with Villanueva Goldner. The red and green signals indicate osteoid and bone tissues, respectively. The osteoid signal at the medial mid-shaft cortical bone was lower in meclozine-treated Hyp mice compared with untreated Hyp mice. Scale bars, 100 µm. (C) OV/BV. Dots indicate the OV/BV of each sample, and bars indicate the mean ± SD. Statistical significance was analyzed using one-way ANOVA with or without Welch's correction. ^*P<0.05, ^**P<0.01. Hyp mice, X-linked hypophosphatemic mice; OV/BV, osteoid volume/bone volume.