Figure 4.

Meclozine partially rescues impaired mineralization of cancellous bone in Hyp mice. Representative non-decalcified histological images of the (A) distal trabecular bone of the femur, (B) proximal trabecular bone of the tibia and (C) proximal trabecular bone of the first tail vertebrae stained with Villanueva Goldner. The red and green signals indicate osteoid and bone tissue, respectively. Scale bars, 100 µm. (D) OV/BV in the tail, femoral and tibial bones. Dots indicate the OV/BV of each sample, and bars indicate the mean ± SD. Statistical significance was analyzed using one-way ANOVA with or without Welch's correction. ^**P<0.01. Hyp mice, X-linked hypophosphatemic mice; OV/BV, osteoid volume/bone volume.