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(A) Schematic illustration of synergistic therapeutic mechanism of I-CaS@PP. (B) CLSM images and (D) corresponding mean fluorescence intensity (MFI) of intracellular H2S level after different treatments for 6 h. Scale bar = 50 μm. (C) CLSM images and (E) corresponding MFI of intracellular Ca2+ concentration after various treatments for 6 h. Scale bar = 50 μm. Data are presented as mean ± SD (n = 3). ∗∗∗P < 0.001. L means NIR laser irradiation, E means EGTA.
