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. 2022 Apr 16;12(12):4446–4457. doi: 10.1016/j.apsb.2022.04.007

Scheme 4.

Scheme 4

Synthesis of compounds P41. Reagents and condition: (a) phenylboronic acid derivatives, Pd(OAc)2, K2CO3, EtOH/H2O (1:1), rt, 14 h, 84%; (b) AcOH, 120 °C, 7 h, 72%; (c) BH3·THF, THF, 10 h, rt, 70%; (d) Dess-Martin periodane, CH2Cl2, rt, 2 h, 75%; (e) DMF, Cs2CO3, 80 °C, 2 h, 80%; (f) appropriate amine, NaBH(OAc)3, CH2Cl2, rt, 10 h, 52%.