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. 2022 Dec 15;82(1):6–20. doi: 10.1093/jnen/nlac090

Table 2.

Neuropathology reports among brain death cases following long intervals

Reference Age Interval Neuropathology Interpretation
Parisi, 1982 (10) (n = 1) 49 y 68 d Transverse dural sinus thrombosis; cortical subpial vascularization and macrophages; “coagulative necrosis but … no evidence of cellular reactivity” of deeper structures “Inward progression of the reparative response from the leptomeningeal surface, presumably originating from the intact extracranial circulation”
Ito, 1992 (36) (n = 1) 14 y 101 d “Proliferation of vessels and fibrosis…[and] erythrocytes, leucocytes and scavenger cells in the dura mater” “Secondary petechial haemorrhage…appear to occur long after the trauma, in spite of the complete cessation of cerebral blood flow … [and] may be produced from newly formed vessels in the dura mater by secondary circulatory disturbances” … [since] the blood flow of the dura is maintained by the middle meningeal artery which originates from the external carotid artery
Repertinger, 2006 (11) (n = 1) 4 y 20 y Calcified shell, with ossification and marrow, grumous mummified material, mineralized cell processes, iron pigment, extensive small focal calcifications “blood flow was insufficient over the 2 decades for macrophages to arrive and remove most of the debris”

d, days; n, number of cases in report; y, years.