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Schematic diagram of mechanisms mediating the protective effect of statins in doxorubicin-induced cardiomyopathy. cam KIId, calcium-calmodulin-dependent protein kinases; DDR, DNA damage response; PLN, phospholamban; PP1, protein phosphatase I; ROS, reactive oxygen species; RyR2, ryanodine receptor 2; Serca2, sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2.
