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. 2022 Nov 3;24(6):742. doi: 10.3892/etm.2022.11678

Figure 2.

Figure 2

Identification of IS-associated genes targeted by GEB. (A) Venn diagram of intersection of drug and disease targets and DEGs. (B) Expression heat map of key target genes between IS and normal samples. Each square represents a gene. The greater the expression, the darker the color (red, upregulated; blue, downregulated expression). Each row represents the expression of each gene in different samples; column represents expression of all genes in each sample. IS, ischemic stroke; GEB, Gastrodia elata Blume; DEG, differentially expressed gene; ADA, adenosine deaminase; APRT, adenine phosphoribosyltransferase; CA1, carbonic anhydrase 1; LCN2, lipocalin 2; MPO, myeloperoxidase; TDP1, tyrosyl-DNA phosphodiesterase 1; PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ; HDAC4, histone deacetylase 4; HK2, hexokinase 2; PPP3CA, protein phosphatase 3 catalytic subunit α; PTGS1, prostaglandin-endoperoxide synthase 1; ALDH2, aldehyde dehydrogenase 1 family member 2; LGALS2, galectin 2; LY96, lymphocyte antigen 96; HMGCR, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase; PTGS1, prostaglandin-endoperoxide synthase 2: SELL, selectin L; ALPL, alkaline phosphatase, biomineralization associated; CA4, carbonic anhydrase 4; MGAM, maltase-glucoamylase; PLOD1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase; ALOX5, arachidonate 5-lipoxygenase; IGFR2, insulin-like growth factor II receptor; G6PD, glucose-6-phosphate dehydrogenase; GAA, α glucosidase; PPP3R1, protein phosphatase 2B regulatory subunit 1; DUSP1, dual specificity phosphatase 1; TLR4, toll-like receptor 4; PTAFR, platelet activating factor receptor; TBXAS1, thromboxane A synthase 1.