Table 1. Comparative Amino Acid Enrichment for Pravastatin and 6-epi-Pravastatin among Rosetta CoupledMoves Designs^a.

	pro-pravastatin		pro-6-epi-pravastatin
position	preferred AA	comparative enrichment (%)	preferred AA	comparative enrichment (%)
P80	A	28.49	G	13.88
T95	V	31.44	I (wild-type)	67.81
M179	M (wild-type)	34.17	L	27.04
V180	V (P450pra)	44.91	A (wild-type)	22.87
V182	V (wild-type)	12.08	A	11.14
T286	F	28.53	L	39.92
A388	A (wild-type)	18.71	N/A	N/A

^aThe differential enrichment of substitutions among Rosetta designs optimized for compactin binding in pro-pravastatin versus pro-6-epi-pravastatin binding mode were calculated. Values represent differences in amino acid abundance in the pravastatin and 6-epi-pravastatin set (eq 1).