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. 2022 Dec 20;50(3):2701–2711. doi: 10.1007/s11033-022-08188-1

Table 1.

Molecular docking analysis of metformin (MET) with the LARP1 and FKBP7

S. No Protein-ligand complex Binding energy (kcal/Mol) Inhibition constant (Ki) H-Bond atom distance H-Bond Atom Active site residues
1 LARP1 + MET −3.99 1.19 mM 2.12895 :MOL0:H17- A:GLU875:OE1 Gly869,Tyr870,Arg871,Tyr872,Glu875
2 FKPB7 + MET −5.41 104.89 µM

1.95899

2.1723

1.96238

:MOL0:H17 - A:GLU127:OE1

:MOL0:H18 - A:SER124:OG

:MOL0:H19 - A:GLU123:OE2

Ser121,Glu123, Ser124,Glu127