Fig. 6.

ZIKV-infection induces a DAM-like phenotype in the brain of immunocompetent CC071 mice susceptible to infection. CC001 and CC071 mice (5–6 week-old) were necropsied at day 6 following IC inoculation of either PBS or 10⁵ FFU of ZIKV. In the brain of CC071 as compared to CC001 mice, ZIKV affects the level of RNA expression of genes associated with a DAM phenotype as determined by RT-qPCR analysis of total brain extracts from ZIKV-infected CC001 and CC071 mice with respect to Hrpt1 used as reference gene. Symbols represent individual mice. Data from n = 5 CC001 and CC071 mice respectively are means without s.d. with significance assessed by two-way ANOVA and Tukey’s multiple comparisons test. P-value < 0.0001 (****), < 0.001 (***), < 0.01 (**) and ns not significant