Table 4.
Tumor and treatment details of patients with any recorded maximum grade 3 to 4 adverse event and whether the event was classified as possibly, probably, or definitely related to radiation therapy
| Tumor site | Radiation therapy | Fractionation (cGy/F) | Adverse event†† | Grade | n n = 26) | RT related (n = 18) |
|---|---|---|---|---|---|---|
| Prostate | MRL only | 6000/20 | Erectile dysfunction | 3 | 8 | 8/8 |
| Prostate | MRL only | 6000/20 | Stroke, erectile dysfunction* | 3 | 1 | 1/1 |
| Prostate | MRL only | 3625/5 | Erectile dysfunction | 3 | 1 | 1/1 |
| Prostate | MRL only | 3625/5 | Progression of multiple myeloma | 3 | 1 | 0/1 |
| Prostate | MRL only | 3862/5 | Respiratory failure, sepsis, flu-like symptoms† | 3 and 4 | 1 | 0/1 |
| Bladder | MRL only | 3600/6 | Bronchial infection | 3 | 1 | 0/1 |
| Bladder | MRL only | 3600/6 | Erectile dysfunction | 3 | 1 | 1/1 |
| Pancreas | MRL only | 5205/28 | Decreased lymphocyte count | 3 | 1 | 0/1 |
| Pancreas | MRL only | 3500/5 | Anemia | 3 | 1 | 0/1 |
| Pancreas | MRL only | 5040/28 | Nausea, diarrhea, abdominal pain, malabsorption, pancreatic enzymes decreased, enterocolitis infection, dehydration‡ | 3 | 1 | 1/1 |
| Peritoneum§ | MRL only | 1400/2 | Heart failure | 3 | 1 | 0/1 |
| Liver | MRL only | 5000/5 | Umbilical hernia | 3 | 1 | 0/1 |
| Liver | MRL only | 4775/5 | Peripheral ischemia | 3 | 1 | 0/1 |
| Hypopharynx | MRL only | 5319/25 | Dysphagia and dry mouth | 3 | 1 | 1/1 |
| Oropharynx | MRL only | 7118/33 | Dysphagia, dry mouth, esophagitis, and oral mucositis | 3 | 1 | 1/1 |
| Oropharynx | MRL only | 5977/28 | Dysphagia, dry mouth, and esophagitis | 3 | 1 | 1/1 |
| Oropharynx | MRL only | 7074/33 | Dry mouth, esophagitis, and oral mucositis | 3 | 1 | 1/1 |
| Oropharynx | Mixed modalities║ | 4991/23# | Lung infection, dysphagia, esophagitis, and dry mouth** | 3 | 1 | 1/1 |
| Larynx | Mixed modalities║ | 3417/17# | Dysphagia, dry mouth, esophagitis, and oral mucositis | 3 | 1 | 1/1 |
Abbreviations: MRL = magnetic resonance-linear accelerators; RT = radiation therapy.
This patient with prostate cancer had a stroke that was classified as unrelated to the MRL treatment.
This patient with prostate cancer experienced respiratory failure and sepsis grade 4 and flu-like symptoms grade 3 due to an infection with the influenza virus, which was classified as unrelated to the radiation therapy.
This patient with pancreatic cancer was dehydrated due to an enterocolitis infection, which was classified as unrelated to the radiation therapy.
Includes retroperitoneal tumor sites.
Course is delivered using the MRL and a conventional linac or other RT method.
Fractionation scheme of MRL treatment, not of the entire course.
This patient with oropharyngeal cancer had a lung infection, which was classified as unrelated to the radiation therapy.
Adverse events were defined as new-onset adverse event grade 3, 4, or 5 according to the National Cancer Institute’s (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v 5.0.