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PARKIN regulated cardiac hypertrophy through targeting mitophagy. After being infected with Parkin adenovirus, cardiomyocytes were treated with 3-methyladenine (3-MA) or PBS, and then exposed to Ang II. A, Cell surface area indicated by phalloidin-TRITC conjugate stained F-actin were calculated. ** p < 0.01. *** p < 0.001. n = 3 experiments per group. B, mRNA levels of ANP and BNP. * p < 0.05. ** p < 0.01. n = 3 experiments per group
