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. 2022 Dec 19;7(1):e001188. doi: 10.1136/bmjophth-2022-001188

Table 2.

Treatment Burden Score linear regression model: Mean

Factors Difference of means 95% CI P value
Lower Upper
Age
 < 63 years old (vs > 80 years old) −4.33 −6.21 −2.45 <0.001
Location
 Northeast (vs Midwest) 4.26 2.54 5.98 <0.001
 Midwest (vs South) 5.99 4.21 7.76 <0.001
 South (vs Northeast) 1.73 0.51 2.94 0.005
Disease
 AMD (vs RVO) 1.29 −0.22 2.79 0.093
 DMO/DR (vs AMD) 1.63 −0.93 2.18 0.028
 RVO (vs DMO/DR) −1.66 −2.31 0.99 0.042
Time of Diagnosis
 < 5 years (vs > 5 years) −0.85 −2.25 0.54 0.23
Frequency of treatment
 Every 4–5 weeks (vs every 10–16 weeks) −1.58 −3.27 0.11 0.066
 Every 10–16 weeks (vs PRN) 0.83 −2.24 3.9 0.596
 PRN (vs every 4–5 weeks) −0.75 −3.62 2.12 0.608
Total number of injections
 < 10 (vs > 50) −1.44 −3.4 0.51 0.148

Patients with no missing data for any of the variables were included in the regression analysis; n=1120.

P value < 0.05 considered to be significant.

AMD, age-related macular degeneration; DMO, diabetic macular oedema; DR, diabetic retinopathy; PRN, pro re nata; RVO, retinal vein occlusion.

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