Table 3.
Incidence and incidence rates after imputation for missing RSV test results and missing medical attendance status of RSV-associated hospitalised ARIs, medically attended ARIs, and ARIs by age group, according to season, recruitment site, cohort, and season of birth
|
RSV-associated hospitalised ARI |
Medically attended RSV-associated ARI |
RSV-associated ARI |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <3 months | 3 to <6 months | 6 to <12 months | <12 months | <3 months | 3 to <6 months | 6 to <12 months | <12 months | <3 months | 3 to <6 months | 6 to <12 months | <12 months | ||
| RSV incidence proportion | |||||||||||||
| Overall | 0·97% (0·82–1·16) | 0·49% (0·38–0·63) | 0·39% (0·29–0·52) | 1·80% (1·58–2·05) | 3·39% (2·56–4·49) | 4·55% (3·55–5·80) | 6·32% (5·13–7·77) | 14·07% (12·31–16·03) | 5·05% (4·01–6·33) | 9·29% (7·84–10·97) | 12·61% (10·93–14·51) | 26·22% (23·95–28·63) | |
| Site | |||||||||||||
| Scotland | 1·15% (0·83–1·60) | 0·47% (0·28–0·79) | 0·73% (0·48–1·10) | 2·31% (1·83–2·92) | 1·48% (0·59–3·64) | 5·72% (3·55–9·11) | 6·75% (4·30–10·45) | 13·74% (10·17–18·31) | 3·50% (1·91–6·33) | 12·69% (9·17–17·3) | 13·60% (9·88–18·43) | 29·21% (24·05–34·97) | |
| England | 1·03% (0·71–1·51) | 0·71% (0·44–1·14) | 0·43% (0·23–0·81) | 1·97% (1·50–2·57) | 2·58% (1·26–5·20) | 5·05% (2·97–8·46) | 3·03 % (1·48–6·09) | 10·4% (7·18–14·84) | 3·99% (2·21–7·11) | 9·95% (6·89–14·15) | 7·61% (4·93–11·55) | 20·51% (15·96–25·94) | |
| Spain | 1·20% (0·77–1·88) | 1·00% (0·60–1·65) | 0·28% (0·11–0·69) | 2·48% (1·81–3·40) | 6·00% (3·77–9·43) | 6·65% (4·27–10·21) | 5·35% (3·22–8·76) | 17·71% (13·65–22·65) | 7·71% (5·10–11·49) | 11·15% (7·98–15·37) | 11·80% (8·50–16·16) | 29·56% (24·49–35·19) | |
| Finland | 0·62% (0·4–0·97) | 0·24% (0·12–0·49) | 0·19% (0·08–0·44) | 1·05% (0·74–1·49) | 1·00% (0·33–2·98) | 1·01% (0·33–2·99) | 4·95% (2·95–8·19) | 6·90% (4·48–10·49) | 1·00% (0·33–2·98) | 2·51% (1·23–5·07) | 7·07% (4·62–10·68) | 10·50% (7·45–14·61) | |
| Netherlands | 0·97% (0·65–1·43) | 0·26% (0·12–0·57) | 0·25% (0·11–0·56) | 1·47% (1·07–2·03) | 6·04% (3·73–9·63) | 4·28% (2·43–7·43) | 11·66% (8·32–16·10) | 21·98% (17·38–27·39) | 9·25% (6·30–13·38) | 10·16% (7·08–14·38) | 23·32% (18·6–28·81) | 42·19% (36·35–48·26) | |
| RSV incidence rate per 1000 infant-months | |||||||||||||
| Overall | 3·26 (2·63–4·04) | 1·67 (1·23–2·27) | 0·65 (0·45–0·92) | 1·56 (1·33–1·82) | 11·69 (8·34–16·38) | 15·21 (11·28–20·52) | 10·77 (8·36–13·88) | 12·11 (10·24–14·34) | 17·55 (13·34–23·1) | 31·69 (25·76–38·98) | 22·81 (19·16–27·17) | 23·70 (21·02–26·73) | |
| Site | |||||||||||||
| Scotland | 3·88 (2·60–5·80) | 1·55 (0·82–2·92) | 1·21 (0·73–2·00) | 1·96 (1·48–2·61) | 4·95 (1·60–15·35) | 19·10 (10·63–34·32) | 11·47 (6·62–19·87) | 11·75 (8·06–17·12) | 11·70 (5·58–24·56) | 44·82 (30·18–66·56) | 24·77 (16·78–36·56) | 26·52 (20·54–34·25) | |
| England | 3·46 (2·20–5·45) | 2·56 (1·47–4·47) | 0·72 (0·34–1·51) | 1·87 (1·38–2·55) | 8·61 (3·58–20·71) | 17·00 (8·89–32·54) | 5·04 (2·09–12·10) | 8·98 (5·69–14·18) | 13·31 (6·44–27·51) | 34·07 (21·68–53·55) | 12·99 (7·63–22·1) | 18·39 (13·4–25·23) | |
| Spain | 4·01 (2·33–6·90) | 3·34 (1·81–6·14) | 0·46 (0·15–1·44) | 2·07 (1·41–3·03) | 20·11 (11·37–35·55) | 22·22 (12·92–38·24) | 8·93 (4·80–16·61) | 15·09 (10·82–21·06) | 27·46 (16·81–44·88) | 37·28 (24·56–56·59) | 20·58 (13·77–30·75) | 26·49 (20·63–34·03) | |
| Finland | 2·07 (1·20–3·56) | 0·80 (0·33–1·92) | 0·31 (0·1–0·9) | 0·87 (0·57–1·33) | 3·34 (0·84–13·35) | 3·35 (0·84–13·41) | 8·24 (4·37–15·52) | 5·79 (3·40–9·85) | 3·34 (0·84–13·35) | 8·38 (3·49–20·14) | 11·78 (6·98–19·89) | 8·81 (5·74–13·51) | |
| Netherlands | 3·23 (2·02–5·18) | 0·86 (0·33–2·27) | 0·40 (0·14–1·15) | 1·23 (0·83–1·81) | 21·93 (12·46–38·57) | 14·27 (7·14–28·54) | 20·28 (13·43–30·64) | 19·20 (14·21–25·93) | 32·63 (20·57–51·77) | 33·90 (21·62–53·15) | 44·48 (33·62–58·85) | 38·89 (31·49–48·02) | |
| Season | |||||||||||||
| 2017–18 | 3·90 (2·51–6·08) | 2·49 (1·21–5·09) | 0* | 2·71 (1·85–3·98) | 15·01 (7·81–28·86) | 11·98 (4·49–31·94) | 0* | 12·05 (7·00–20·75) | 20·75 (11·75–36·67) | 18·08 (8·03–40·72) | 0* | 17·15 (10·79–27·26) | |
| 2018–19 | 3·17 (2·30–4·38) | 1·41 (0·83–2·41) | 0·90 (0·50–1·62) | 1·76 (1·38–2·25) | 8·36 (4·75–14·71) | 9·79 (5·50–17·46) | 10·37 (6·64–16·19) | 9·60 (7·12–12·95) | 12·10 (7·56–19·38) | 20·32 (13·60–30·37) | 21·30 (15·62–29·05) | 18·19 (14·67–22·55) | |
| 2019–20 | 3·03 (2·10–4·36) | 1·79 (1·17–2·76) | 0·74 (0·47–1·15) | 1·45 (1·14–1·83) | 14·90 (8·66–25·64) | 21·24 (14·44–31·24) | 12·65 (9·26–17·29) | 15·06 (12·04–18·83) | 24·32 (15·89–37·22) | 46·16 (35·79–59·54) | 27·20 (21·99–33·66) | 31·25 (26·81–36·42) | |
| Cohort | |||||||||||||
| Cohort A | 2·92 (1·48–5·77) | 2·45 (1·13–5·29) | 0·72 (0·27–1·91) | 1·71 (1·08–2·69) | .. | .. | .. | .. | .. | .. | .. | .. | |
| Cohort P without cohort A | 3·30 (2·63–4·14) | 1·57 (1·13–2·19) | 0·64 (0·44–0·93) | 1·54 (1·30–1·82) | .. | .. | .. | .. | .. | .. | .. | .. | |
| Sex | |||||||||||||
| Female | 3·16 (2·31–4·32) | 1·44 (0·90–2·30) | 0·55 (0·32–0·93) | 1·42 (1·13–1·80) | 10·68 (6·45–17·71) | 11·37 (6·94–18·63) | 11·49 (8·07–16·37) | 11·26 (8·77–14·46) | 17·39 (11·66–25·92) | 28·39 (20·73–38·89) | 23·99 (18·8–30·61) | 23·43 (19·71–27·84) | |
| Male | 3·38 (2·53–4·51) | 1·89 (1·24–2·88) | 0·74 (0·47–1·17) | 1·69 (1·37–2·08) | 12·65 (8·05–19·86) | 18·82 (12·87–27·52) | 10·09 (7·04–14·48) | 12·92 (10·31–16·19) | 17·73 (12·08–26·03) | 34·16 (25·81–45·21) | 21·72 (16·98–27·78) | 23·82 (20·16–28·14) | |
| Season of birth† | |||||||||||||
| Spring | 0·47 (0·15–1·45) | 0·77 (0·31–1·95) | 1·02 (0·56–1·83) | 0·82 (0·51–1·31) | 0* | 6·15 (2·45–15·40) | 18·52 (12·77–26·86) | 10·72 (7·60–15·12) | 0* | 16·71 (9·70–28·77) | 42·87 (33·49–54·87) | 25·43 (20·31–31·83) | |
| Summer | 1·55 (0·86–2·80) | 4·24 (2·92–6·15) | 0·29 (0·10–0·82) | 1·60 (1·18–2·16) | 8·17 (3·90–17·14) | 36·82 (25·64–52·88) | 2·03 (0·65–6·30) | 12·32 (9·01–16·83) | 14·99 (8·66–25·95) | 78·13 (61·17–99·79) | 4·92 (2·39–10·15) | 25·81 (20·85–31·95) | |
| Autumn | 8·53 (6·60–11·04) | 1·35 (0·70–2·61) | 0·17 (0·04–0·65) | 2·57 (2·03–3·25) | 31·56 (20·95–47·55) | 11·37 (5·69–22·73) | 1·48 (0·37–5·91) | 11·55 (8·19–16·27) | 46·95 (33·56–65·67) | 17·83 (9·98–31·88) | 4·22 (1·90–9·40) | 18·41 (13·99–24·23) | |
| Winter | 2·03 (1·18–3·48) | 0·15 (0·02–1·05) | 1·17 (0·7–1·95) | 1·13 (0·78–1·62) | 7·23 (2·71–19·29) | 0* | 25·22 (17·40–36·55) | 14·41 (10·17–20·41) | 7·23 (2·71–19·29) | 0* | 46·33 (35·24–60·90) | 24·97 (19·17–32·51) | |
| Birthweight | |||||||||||||
| <2500 g | 5·78 (1·86–17·91) | 0* | 0* | 1·49 (0·48–4·63) | 0* | 38·45 (11·15–132·56) | 6·94 (0·98–49·29) | 13·42 (4·87–36·98) | 0* | 72·07 (30·01–173·09) | 7·44 (1·05–52·97) | 22·04 (9·96–48·75) | |
| ≥2500 g | 3·18 (2·55–3·96) | 1·69 (1·25–2·30) | 0·66 (0·47–0·95) | 1·55 (1·32–1·82) | 12·04 (8·59–16·88) | 14·72 (10·77–20·12) | 10·94 (8·47–14·13) | 12·16 (10·25–14·43) | 18·10 (13·75–23·82) | 30·54 (24·63–37·87) | 23·17 (19·43–27·62) | 23·73 (21·01–26·81) | |
Data are % (95% CI) or incidence rate (95% CI). ARI=acute respiratory infection. A=active surveillance. P=passive surveillance. RSV=respiratory syncytial virus.
*
Incidence rate estimated as 0, 95% CI not determined because of 0 cases.
†
Season of birth was defined as: spring from March 21 to June 20, summer from June 21 to Sept 20, autumn from Sept 21 to Dec 20, and winter from Dec 21 to March 20.