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Recommendations for definitive therapy by the MIC of cefotaxime
| Cefotaxime MIC | Therapya |
|---|---|
| <1 mg/L | Ceftriaxone 100 mg/Kg with 4 g as maximum dose |
| 1 to 2 mg/L | Cefotaxime 300 mg/Kg/d in 4 divided doses |
| >2 mg/L | Cefotaxime 300 mg/Kg/d in 4 divided doses + vancomycin 30 mg/Kg/12 h |
| Allergy | Vancomycin 30 mg/Kg/12 h + rifampicin15 mg/Kg/24 h 900 mg/24 h maximum dose |
Always check serum vancomycin levels when using vancomycin. Avoid penicillin, ampicillin, and vancomycin as monotherapy.
