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Log linear associations between day 1 aztreonam exposures and highest observed ALT/AST values in the generalized linear model analyses among subjects who received 2-h intermittent infusions of aztreonam. (A) ALT versus AUC0–24; (B) AST versus AUC0–24; (C) ALT versus Cmax; (D) AST versus Cmax; (E) ALT versus Cmin; (F) AST versus Cmin. ALT, alanine aminotransferase; AST, aspartate aminotransferase; ATM, aztreonam; AUC, area under the curve; D1, day 1.
