TABLE 1.
Comparison of ESKAPE Act PLUS to existing applicationsa
| Application | Type | Prokaryotes | Analysis | Visualization | Pathway graphs |
|---|---|---|---|---|---|
| ESKAPE act plus | AA | YES | GO & KEGG | YES | YES |
| STRING (7) | ORA | YES | GO & KEGG | NO | NO |
| ShinyGO (8) | ORA | YES | GO only | YES | NO |
| DAVID (9, 10) | ORA | YES | GO & KEGG | YES | YES |
| ProkSeq (11) | ORA | YES | GO & KEGG | YES | NO |
| WebGestalt (29) | ORA | NO | GO & KEGG | YES | NO |
| GOrilla (30) | ORA | NO | GO only | YES | NO |
| g:Profiler (31) | ORA | NO | GO & KEGG | YES | NO |
| Ingenuity Pathway Analysis (6) | AA | NO | Pathways & Functions | YES | YES |
a
The first column contains the name and reference for each application, column two describes the type of analysis, activation analysis (AA) or overrepresentation analysis (ORA); column 3 indicates whether analysis of prokaryotic data is supported; column 4 contains available analyses, column 5 shows whether there is a graphical output comparing the significance of KEGG pathways or GO terms in addition to tables; and column 6 indicates the availability of pathway-level visualizations that highlight the differentially expressed genes or proteins provided by the user.