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. Author manuscript; available in PMC: 2022 Dec 20.
Published in final edited form as: J Physiol. 2021 Dec 12;600(2):299–312. doi: 10.1113/JP282157

Figure 5. Subunit dependence of KATP channels in atrial myocytes.

Figure 5.

A and B, representative inside-out patch-clamp recordings from ACM in the presence of differing [ATP], as in Fig. 2A, from KATP subunit knockout fish (A) and Cantú mutant fish (B). with (right) or without (left) Mg2+ ions. C, measured KATP density (current in zero ATP) from individual experiments as in A and B (n = 3–12 recordings, from 1–3 preparations (four animals per preparation), in each case). D, [ATP] dependence of channel activity (Irel) from recordings as in A and B. (above) Dose-response relationships were fitted with Hill plots (eqn (1)). Graph shows fit to averaged data; inset shows individual data, mean and SD for fits to individual recordings.