Figure 6. Subunit dependence of K_ATP channels in bulbous arteriosus myocytes.

A, left: representative whole-cell voltage-clamp recordings from WT BA smooth muscle myocytes with zero 0.1 mM ATP in the recording pipette. Currents were recorded with 136 mM Na⁺/6 mM K⁺ (Na⁺) in the bath or 0 Na⁺/140 K⁺ (K⁺) as indicated. Right: measured K current density (current in K⁺ – current in Na⁺) from individual experiments as at left (n = 4 recordings from 2 preparations (five animals per preparation), in each case). B, left: representative whole-cell voltage-clamp recordings from Kir6.1 knockout and hetero- or homozygous Cantú mutant zebrafish as indicated. Right: measured K⁺ current density (current in K⁺ – current in Na⁺) from individual experiments as at left (n = 3–10 recordings from 1–3 preparations (five animals per preparation), in each case).