(A) Greater relative abundance of longer unsaturated triacylglycerols (TAGs) in the serum of adults with progressive (n = 32) versus non-progressive (n = 60) eGFR decline. (B) A similar pattern was found when all participants were grouped based on whether they achieved a sustained GFR <90 (n = 33), <60 (n = 13), and <30 mL/min (n = 6). (C) Lower relative abundance of longer unsaturated acylcarnitines (ACs) in adults with progressive versus non-progressive eGFR decline. (D) A similar trend was noted in abundance of ACs by carbon number, when all participants were grouped based on whether they achieved a sustained GFR <90 (n = 33), <60 (n = 13), or <30 mL/min (n = 6). Reprinted from Afshinnia F et al., JCI Insight 2019. Reprinted with permission of American Society for Clinical Investigation, from JCI Insight, “Increased lipogenesis and impaired β-oxidation predict type 2 diabetic kidney disease progression in American Indians,” Afshinnia et al., 21:4, 2019; permission conveyed through Copyright Clearance Center, Inc.