TABLE 4.

In vitro activity of CUO246 against an isogenic panel of S. aureus QRDR mutants^a

S. aureus mutants	Relevant characteristic	MIC (μg/mL)
		CUO246	MOX	NOR
Parent (ATCC 29213)		0.25	0.06	1
NB01001-DLR0024	GyrA S84L (TCA→TTA)	0.5	0.12	1
NB01001-DLR0027	GrlA S80Y (TCC→TAC)	0.25	0.12	16
NB01001-DLR0028	GrlA S80F (TCC→TTC)	0.25	0.25	16
NB01001-DLR0133	GrlA E84L (GAA→AAA)	0.25	0.12	32
NB01001-DLR0056	GyrA S84L (TCA→TTA), GrlA S80F (TCC→TTC)	1	2	128
NB01001-DLR0060	GyrA S84L (TCA→TTA), GrlA S80Y (TCC→TAC)	1	2	64
NB01001-DLR0064	GyrA S84L (TCA→TTA), GrlA E84L (GAA→AAA)	0.25	2	64

^aMOX, moxifloxacin; NOR, norfloxacin.