TABLE 1.
MIC of GEPO and other comparator drugs against NTM strains
| Antibiotic | MIC (mg/L)a |
|||||||
|---|---|---|---|---|---|---|---|---|
| Fast-growing NTMs |
Slow-growing NTMs |
|||||||
| M. fortuitum ATCC 6841 | M. chelonae ATCC 35752 | M. abscessus ATCC 19977 | M. avium ATCC 19698 | M. gordonae ATCC 14470 | M. nonchromogenicum ATCC 19530 | M. kansasii ATCC 12478 | M. intracellulare ATCC 13950 | |
| Gepotidacin | 2 | 2 | 2 | 16 | 16 | 32 | 32 | 16 |
| Amikacin | 2 | 2 | 8 | 2 | 2 | 2 | 4 | 1 |
| Ceftazidime | >64 | >64 | >64 | NT | NT | NT | NT | NT |
| Ceftriaxone | >64 | >64 | >64 | NT | NT | NT | NT | NT |
| Levofloxacin | 0.06 | 0.12 | 2 | NT | NT | NT | NT | NT |
| Moxifloxacin | 0.03 | 0.03 | 2 | 2 | 1 | 1 | 1 | 0.5 |
| Clarithromycin | 1 | 1 | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 | 0.12 |
a
NT, not tested.