TABLE 3.
Determination of the interaction of GEPO with front-line antimycobacterial drugs against M. fortuitum ATCC 6841, M. abscessus ATCC 19977, and M. tuberculosis ATCC 27294
| Strain and drugs | MIC of drug alone (mg/L) | MIC of drug in presence of gepotidacin (mg/L) | MIC of gepotidacin alone (mg/L) | MIC of gepotidacin in presence of drug (mg/L) | FIC index | Indication |
|---|---|---|---|---|---|---|
| M. fortuitum ATCC 6841 | ||||||
| Amikacin | 0.5 | 0.25 | 1 | 0.125 | 0.62 | No interaction |
| Meropenem | 1 | 0.25 | 1 | 0.06 | 0.31 | Synergistic |
| Moxifloxacin | 0.06 | 0.0075 | 1 | 0.125 | 0.25 | Synergistic |
| Clarithromycin | 1 | 0.5 | 1 | 0.25 | 0.75 | No interaction |
| Ciprofloxacin | 0.06 | 0.015 | 1 | 0.125 | 0.37 | Synergistic |
| Linezolid | 1 | 0.06 | 1 | 0.125 | 0.18 | Synergistic |
| Vancomycin | 0.25 | 0.25 | 1 | 0.06 | 1.06 | No interaction |
| M. abscessus ATCC 19977 | ||||||
| Amikacin | 2 | 0.5 | 2 | 0.125 | 0.31 | Synergistic |
| Clarithromycin | 0.5 | 0.5 | 2 | 1 | 1.5 | No interaction |
| Moxifloxacin | 2 | 0.5 | 2 | 0.06 | 0.28 | Synergistic |
| Ciprofloxacin | 1 | 0.125 | 2 | 0.125 | 0.18 | Synergistic |
| M. tuberculosis ATCC 27294 | ||||||
| Isoniazid | 0.03 | 0.0075 | 1 | 0.015 | 0.265 | Synergistic |
| Rifampicin | 0.06 | 0.03 | 1 | 0.5 | 1 | No interaction |
| Ethambutol | 1 | 0.5 | 1 | 0.5 | 1 | No interaction |
| Streptomycin | 1 | 0.5 | 1 | 0.25 | 0.75 | No interaction |