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. 2022 Oct 26;7(6):e00358-22. doi: 10.1128/msystems.00358-22

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Copyright © 2022 Dooling et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — L. reuteri corrects social deficits in Shank3B^−/−-Rag2^−/− mice. (A) Schematic of the three-chamber social behavior test. (B) Schematic of the experimental design. (C) Social interaction in vehicle- and L. reuteri-treated WT, Shank3B^−/−, and Shank3B^−/−-Rag2^−/− mice in the three-chamber test (n = 8 to 9 per group; WT littermate: t = 2.929, P = 0.0194; Shank3B^−/−: t = 0.9491, P > 0.9999; Shank3B^−/− + L. reuteri: t = 4.738, P < 0.0001; Shank3B^−/−-Rag2^−/− + vehicle: t = 0.4571, P > 0.9999; Shank3B^−/−-Rag2^−/− + L. reuteri: t = 6.247, P < 0.0001 [two-way ANOVA with Bonferroni correction, F_(4,68) = 10.34; P < 0.0001]). *, P < 0.05; ****, P < 0.0001; ns, nonsignificant. Bar graphs show means ± the SEM with individual data points.