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. 2022 Oct 26;7(6):e00358-22. doi: 10.1128/msystems.00358-22

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Copyright © 2022 Dooling et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — L. reuteri increases oxytocin levels in the PVN of the hypothalamus in Shank3B^−/− Rag2^−/− mice. (A) Oxytocin immunoreactivity in the PVN of Shank3B^−/−-Rag2^−/− mice treated with either vehicle or L. reuteri. (B) Oxytocin-positive cell (n = 4 mice per group; Shank3B^−/−-Rag2^−/− + vehicle versus Shank3B^−/−-Rag2^−/− + L. reuteri [unpaired t test, t = 2.519, P = 0.0453]). (C) Oxytocin immunofluorescence intensity (n = 4 mice per group; Shank3B^−/−-Rag2^−/− + vehicle versus Shank3B^−/−-Rag2^−/− + L. reuteri [unpaired t test, t = 3.124, P = 0.0205]). *, P < 0.05. Bar graphs show means ± the SEM with individual data points.