FIG 8.

Schematic representing a model detailing how Hal9 governs MMV688766 susceptibility in S. cerevisiae. Under normal physiological conditions, Hal9 regulates the activity of Msn2, Msn4, Hsp12, and unknown regulators to regulate membrane organization and membrane stress responses. MMV688766 exposure impairs lipid homeostasis leading to the induction of membrane stress. When Hal9 function is impaired, increased signaling through Msn2 and Msn4 drives the upregulation of Hsp12, which activates key membrane stress responses important for compound-induced membrane stress.