TABLE 2.
Slopes from a linear mixed-effects model for CSF in the rabbit model of cryptococcal meningitis
| Treatment | Change in Log10 CFU/mL/day |
|||
|---|---|---|---|---|
| Slope | SE | Lower confidence level | Upper confidence level | |
| Control | 0.12 | 0.03 | 0.06 | 0.19 |
| Fluconazole | −0.19 | 0.04 | −0.27 | −0.11 |
| Amphotericin B | −0.33 | 0.04 | −0.41 | −0.25 |
| Fosmanogepix | −0.02 | 0.04 | −0.09 | 0.06 |
| APX2039 (25 mg/kg, QD) | 0.01 | 0.04 | −0.07 | 0.09 |
| APX2039 (50 mg/kg, QD) | −0.04 | 0.05 | −0.13 | 0.05 |
| APX2039 (75 mg/kg, QD) | −0.27 | 0.05 | −0.36 | −0.17 |
| APX2039 (50 mg/kg, BID) | −0.62 | 0.04 | −0.71 | −0.54 |