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. 2022 Nov 3:eabq4064. doi: 10.1126/scitranslmed.abq4064

Fig. 3. S-217622 retains antiviral activity against SARS-CoV-2 VOCs in vivo.

Fig. 3.

Hamsters were intranasally inoculated with 5,000 pfu of SARS-CoV-2 Alpha, Gamma, and Omicron variants. The hamsters were treated with oral administration of S-217622 (200 mg/kg) or vehicle (0 mg/kg) twice a day from the time of inoculation (0 hpi) to 3 dpi (n = 4 for each group). Lung tissues were harvested at 4 dpi. (A) Relative viral RNA abundance in the lungs as compared with lungs from vehicle-treated hamsters were examined. Data were normalized to Actb. (B) Virus titers in the lungs were measured by plaque assay. The values shown are mean ± SD. *p < 0.05 by two-tailed Mann-Whitney test.