FIG 4.

Shared antibiotic resistance genes between CNH, CNS, and HKH groups. (a) The Venn plot of the numbers of ARGs shared by pairs of host groups. (b) Ternary plot of shared ARGs for each pair of hosts. The size of the dot indicates the abundance of ARGs in human of Hong Kong. (c) The number of ARGs in each class shared by three groups of hosts (n = 158). (d) Heatmap of the frequencies of insertion elements associated with ARGs higher than 0.005 in all three groups of hosts. Two-ways clustering in column and row were performed. (e) The frequencies of taxonomic groups on the genera level that carry ARGs and insertion element Tn4451/Tn4453 in all three groups of hosts. (f) Network of ARG-associated insertion sequences in three types of hosts. The size of the shape represents of the relative abundance of ARGs. The color stands for the class of antibiotic to which ARGs are resistant. The shape shows the type of hosts or insertion elements. The scores that represent the ratios of ARGs associated with ISs are illustrated as a color gradient of links between nodes. CNS, China swine; HKH, Hong Kong human; CNH, China human.