FIG 1.

Profiling of total noise, promoter-independent extrinsic noise, promoter-specific intrinsic noise and NTR (expression noise brought about by transcriptional regulation) (a to f) ${\eta }_{\text{total}}^2$ (a and d), ${\eta }_{\text{global}}^2$ (b and e), and ${\eta }_{\text{int,promoter}}^2$ (c and f) of promoter expression plotted against mean SfGFP number in cells for 3,025 reporter strains. EXP, exponential phase; STA, stationary phase. Running medians (smoothing window of 50) are shown in panels b and e (light gray line), fitting curves (light gray) with the relationship ${\eta }_{\text{int}}^2$ = (b + 1)/<n> are shown in panels c and f. NTR is represented by the double-headed arrow in panel c. (g and h) Circos plot of promoter expression data in the exponential (g) and stationary (h) growth phases for 3,025 reporters in correspondence to their genomic locations. Traits from outer ring to inner ring: NTR (purple bar), ${\eta }_{\text{total}}^2$ (light red dot), ${\eta }_{\text{global}}^2$ (light orange dot), and ${\eta }_{\text{int,promoter}}^2$ (light blue dot), mean SfGFP copy number (column of heatmap).