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. 2022 Oct 26;13(6):e02215-22. doi: 10.1128/mbio.02215-22

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Copyright © 2022 van Rhijn et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — RNA-seq analysis of ΔdevR and ΔacdX exposed to olorofim. (A) KEGG pathways enriched for downregulated (blue) or upregulated (red) genes in RPMI 1640 or upon olorofim exposure for ΔdevR compared to A. fumigatus A1160p+. (B) Heatmap of genes involved in the pyrimidine pathway and components upstream of this pathway. (C) KEGG pathways enriched for downregulated (blue) or upregulated (red) genes in RPMI 1640 or upon olorofim exposure for ΔacdX compared to A. fumigatus MFIG001. (D) Detailed analysis of genes involved in pathways upstream of and including the pyrimidine pathway. The target of olorofim, DHODH, is highlighted. Blue denotes more than 1-fold downregulated, yellow denotes more than 1-fold upregulated, and red denotes more than 5-fold upregulated. The right of each box is associated with ΔacdX and the left with ΔdevR.