Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 26;13(6):e02215-22. doi: 10.1128/mbio.02215-22

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 van Rhijn et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

PMC Copyright notice

FIG 6 — Antagonism between olorofim and the azoles through dysregulation of the pyrimidine pathway. (A) Antagonism for the TF mutants with differential susceptibility to olorofim (n = 6) (B) Broth microdilution assay by EUCAST methodology to olorofim for MFIG001 and the generated tetOFF mutants in the pyrimidine pathway (n = 3). (C) The halo size for the generated tetOFF mutants in the pyrimidine pathways to voriconazole and olorofim (n = 4). Statistical significance was assessed using a one-way ANOVA with Dunnett’s correction (P < 0.05 are shown). (D) Antagonism for the tetOFF mutants within the pyrimidine pathway (n = 6). Statistical significance was assessed using a one-way ANOVA with Dunnett’s correction (P < 0.05 are shown).