TABLE 2.

Clinical sensitivity, specificity, and positive and negative predictive values of synovial fluid culture and the targeted metagenomic sequencing-based approach (tMGS) in 36 periprosthetic joint infection and 118 non-infectious arthroplasty failure cases

	Sensitivity %, [95% CI]	Specificity %, [95% CIb]	Positive predictive value %, [95% CI]	Negative predictive value %, [95% CI]
Synovial fluid culture	72 [56−84]	100 [97−100]	100 [87−100]	92 [86−96]
Synovial fluid tMGS	69 [53−82]	100 [97−100]	100 [87−100]	91 [85−95]
Synovial fluid, 16S rRNA PCR and interpretable Sanger sequencing results	53 [37−68]	100 [97−100]	100 [83−100]	87 [81−92]
Synovial fluid culture and/or tMGS	83a [68−92]	100 [97−100]	100 [89−00]	95 [90−98]

^aP < 0.05 compared to synovial fluid culture alone.

^bCI: confidence interval.