TABLE 1.
Defining the SNPs of the Lro cluster
| Position | Gene | Synonym | Reference > Lro | Coding change | Gene function |
|---|---|---|---|---|---|
| 314778 | rv0262c | aac | 77A > C | Q26P | Aminoglycoside resistance |
| 361159 | rv0296c-rv0297 | rv0296c-PE_PGRS5 | Intergenic T > C | Intergenic | |
| 627340 | rv0536 | galE3 | 93C > T | Synonymous | Epimerase (cell wall) |
| 1199991 | rv1075c | rv1075c | 380G > A | G127D | Conserved exported |
| 1519740 | rv1353c | rv1353c | 246C > G | I82M | Probably transcriptional regulator |
| 1728055 | rv1527c | pks5 | 355G > A | G119S | Polyketide synthase |
| 1814105 | rv1614 | lgt | 935C > T | A312V | Maturation of lipoproteins |
| 1986839 | rv1754c-rv1755c | rv1754c-plcD | Intergenic T > C | Intergenic | |
| 2011808 | rv1777 | cyp144 | 1153T > G | C385G | Cytochrome P450 heme monooxygenase |
| 2363071 | rv2101 | helZ | 2832C > A | D944E | Helicase |
| 3183542 | rv2872 | vapC43 | 161G > A | R54H | Toxin antitoxin system |
| 3265893 | rv2934 | ppsD | 3646G > A | A1216T | PDIM biosynthesis |
| 3630522 | rv3250c | rubB | 45G > C | E15D | Rubredoxin |
| 3646060 | rv3265c | wbbL1 | 825G > A | Synonymous | Glycosyltransferase (cell wall) |
| 4316405 | rv3843c | rv3843c | 192C > T | Synonymous | Membrane protein |