TABLE 2.
Metabolic pathways common to clinical and reference strains
| Pathway and subsystem | No. of subsystems (no. of genes) in: |
|||
|---|---|---|---|---|
| B-4156 | Mbale | Mbale2 | Mbale3 | |
| Metabolism | 91 (745) | 93 (767) | 92 (742) | 94 (768) |
| Cofactors, vitamins, and prosthetic groups | 21 (228) | 22 (246) | 20 (231) | 21 (227) |
| Amino acids and derivatives | 29 (227) | 29 (225) | 29 (220) | 29 (241) |
| Fatty acids, lipids, and isoprenoids | 11 (88) | 11 (91) | 11 (88) | 11 (92) |
| Carbohydrates | 9 (64) | 8 (65) | 9 (60) | 9 (69) |
| Nucleosides and nucleotides | 8 (64) | 9 (62) | 8 (62) | 4 (27) |
| Iron acquisition and metabolism | 4 (25) | 4 (25) | 4 (28) | 4 (17) |
| Phosphate metabolism | 1 (20) | 2 (21) | 2 (12) | 2 (15) |
| Metabolite damage and mitigation | 4 (17) | 4 (17) | 4 (25) | 2 (7) |
| Secondary metabolism | 2 (7) | 2 (10) | 2 (10) | 2 (5) |
| Nitrogen metabolism | 1 (4) | 1 (4) | 2 (5) | 2 (5) |
| Sulfur metabolism | 1 (1) | 1 (1) | 1 (1) | 1 (1) |
| Protein processing | 44 (249) | 43 (255) | 42 (237) | 41 (225) |
| Protein synthesis | 31 (201) | 31 (203) | 30 (188) | 29 (177) |
| Protein fate | 13 (48) | 12 (52) | 12 (49) | 12 (48) |
| Energy | 28 (205) | 29 (218) | 27 (209) | 29 (235) |
| Energy and precursor metabolite generation | 18 (124) | 20 (141) | 18 (134) | 20 (159) |
| Respiration | 10 (81) | 9 (77) | 9 (75) | 9 (76) |
| Cellular processes | 27 (174) | 27 (183) | 27 (175) | 26 (175) |
| Cell cycle, cell division, and death | 11 (82) | 11 (82) | 13 (82) | 11 (83) |
| Prokaryotic cell differentiation | 13 (77) | 13 (83) | 11 (78) | 12 (77) |
| Mobility and chemotaxis | 1 (9) | 1 (9) | 1 (9) | 1 (9) |
| Clustering-based subsystems | 1 (5) | 1 (8) | 1 (5) | 1 (5) |
| Microbial communities | 1 (1) | 1 (1) | 1 (1) | 1 (1) |
| Stress response, defense, virulence | 36 (120) | 17 (119) | 32 (121) | 31 (124) |
| Resistance to antibiotics and toxic compounds | 19 (66) | 17 (61) | 15 (65) | 15 (124) |
| Stress response: heat/cold | 2 (17) | 2 (22) | 2 (18) | 2 (17) |
| Stress response: osmotic stress | 4 (13) | 7 (13) | 4 (13) | 7 (15) |
| Stress response: electrophile toxicity | 1 (4) | 1 (4) | 1 (4) | 1 (4) |
| Host-pathogen interactions | 11 (72) | 1 (1) | 1 (1) | 2 (6) |
| DNA processing | 18 (89) | 19 (117) | 18 (90) | 19 (116) |
| DNA repair | 12 (59) | 13 (96) | 12 (60) | 13 (84) |
| DNA uptake, competence | 2 (16) | 2 (28) | 2 (15) | 2 (16) |
| DNA recombination | 2 (5) | 1 (4) | 2 (6) | 2 (5) |
| DNA replication | 1 (4) | 1 (2) | 1 (4) | 1 (5) |
| Membrane transport | 11 (72) | 11 (68) | 7 (63) | 7 (68) |
| ABC transporters | 1 (42) | 1 (41) | 1 (42) | 1 (41) |
| Cation transporters | 4 (22) | 3 (17) | 3 (17) | 3 (21) |
| Multidrug efflux systems | 2 (3) | 2 (3) | 2 (3) | 2 (4) |
| Protein secretion systems, type VII | 3 (4) | 0 (0) | 0 (0) | 0 (0) |
| Protein secretion systems, type II | 1 (1) | 1 (2) | 1 (1) | 1 (2) |
| Uniporter, Symporter, Antiporter | 0 (0) | 1 (1) | 0 (0) | 0 (0) |
| RNA processing | 12 (52) | 12 (54) | 12 (51) | 2 (16) |
| Cell envelope | 3 (15) | 3 (15) | 3 (14) | 1 (6) |
| Regulation and cell signaling | 3 (12) | 3 (12) | 3 (14) | 3 (14) |