FIG 1.

Architecture of the members of RNNPPA family and signaling process. (A) Domain architecture of the different subfamilies of RRNPPA proteins. (B) Diagram of the signaling process in the RRNPPA family. The QS propeptide is encoded immediately upstream or downstream of the RRNPPA gene. When the propetide encodes a single peptide pheromone, the mature QS pheromone (located at the C-terminal region of the propeptide) is created by an N-terminal cut performed by the signal peptidase (SP) and exported by the SEC translocon. Mature QS pheromone is internalized by the oligopeptide permease (OPP); cytoplasmic pheromone can bind to the RRNPPA receptor, modulating its function.